cytoplasmic and membranous cd24 marker expression has indirect correlation with camp/cgmp ratio

background- cd24 is a cell adhesion molecule that has been implicated in metastatic tumor progression cells. our aim was clarify correlation between cd24 expression and camp:cgmp ratio in murine colorectal cancer cell line (ct26) after using cholera toxin. materials and methods- the ct26 cells were cultured in microtubes for assaying camp and cgmp; also the cells were cultured in flasks for assaying cytoplasmic and membranous cd24 expression. the real-time pcr was done for cdna that was synthesized from ct26 cells’ mrna. also, expression cd24 marker of cells was determined by anti-cd24 antibody and goat anti-rabbit igg-fitc (flow cytometry). results- the cholera toxin grew camp:cgmp ratio and it influenced cytoplasmic and membrane cd24 expression. conclusion- there are indirect correlation between camp:cgmp ratio and cd24 expression.